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Targeted Allele Detail
Symbol: Isg15tm1Kpk
Name: ISG15 ubiquitin-like modifier; targeted mutation 1, Klaus-Peter Knobeloch
MGI ID: MGI:3586990
Synonyms: ISG15-
Gene: Isg15  Location: Chr4:156199455-156200796 bp, - strand  Genetic Position: Chr4, 88.61 cM
Germline Transmission:  Earliest citation of germline transmission: J:100028
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA floxed PGK-neo cassette replaced the complete coding region. Northern blot of mutant bone marrow failed to detect transcript. Western blot failed to detect protein in mutants. (J:100028)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 10 assay results
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Isg15 Mutation:  1 strain or line available
Original:  J:100028 Osiak A, et al., ISG15, an interferon-stimulated ubiquitin-like protein, is not essential for STAT1 signaling and responses against vesicular stomatitis and lymphocytic choriomeningitis virus. Mol Cell Biol. 2005 Aug;25(15):6338-45
All:  20 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory