Tg(TcraTcrbNY8.3)1Pesa
Transgene Detail

Summary

• Symbol: Tg(TcraTcrbNY8.3)1Pesa
• Name: transgene insertion 1, Pere Santamaria
• MGI ID: MGI:3584121
• Synonyms: 8.3TCR, 8.3-TCR, 8.3-TCR-alpha/beta transgene, 8.3-TCR-TG, NY8.3, Tcr8.3
• Transgene: Tg(TcraTcrbNY8.3)1Pesa Location: unknown
• Alliance: Tg(TcraTcrbNY8.3)1Pesa page

Transgene origin

• Strain of Origin: (SJL x C57BL/6)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(TcraTcrbNY8.3)1Pesa expresses 2 genes
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Tcra (MGI:98553)
  mouse	Tcrb (MGI:98578)

• Mutation details: Functional VDJbeta and VJalpha rearrangements were isolated from the beta cell cytotoxic CD8(+) T cell clone NY8.3. Upstream regulatory sequence together with either TCR-beta enhancers or TCR-alpha enhancers, as appropriate, were associated with VDJbeta or VJalpha. (J:44202)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:44202 Verdaguer J, et al., Spontaneous autoimmune diabetes in monoclonal T cell nonobese diabetic mice. J Exp Med. 1997 Nov 17;186(10):1663-76
• All: 73 reference(s)