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Transgene Detail
Symbol: Tg(Col2a1-PTHR1*H223R)AHju
Name: transgene insertion A, Harald Juppner
MGI ID: MGI:3584013
Synonyms: CaPpr, Tg-A
Transgene: Tg(Col2a1-PTHR1*H223R)AHju  Location: unknown  
Skeletal images of wild-type and Tg(Col2a1-PTHR1*H223R)AHju/Tg(Col2a1-PTHR1*H223R)AHju mice

Show the 5 phenotype image(s) involving this allele.

Strain of Origin:  C57BL/6
Transgene Type:    Transgenic (Constitutively active, Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
Tg(Col2a1-PTHR1*H223R)AHju expresses 1 gene
Mutation detailsA 1,880-bp cDNA fragment encoding the constitutively active human PTHR1 containing an H223R mutation (HKrk-H223R) was placed downstream of the rat alpha (II) collagen promoter. The A line contains only one copy of the transgene. (J:77639)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Original:  J:77639 Schipani E, et al., Targeted expression of constitutively active receptors for parathyroid hormone and parathyroid hormone-related peptide delays endochondral bone formation and rescues mice that lack parathyroid hormone-related peptide. Proc Natl Acad Sci U S A. 1997 Dec 9;94(25):13689-94
All:  7 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
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