Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Col2a1-cre)#Amc mutation
(0 available)
Tg(Col2a1-PTHR1*H223R)AHju mutation
(0 available)
Zfp521tm1Ngc mutation
(0 available);
any
Zfp521 mutation
(51 available)
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skeleton
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N |
• mice exhibit normal bone length
• tibial growth plate of mutants is similar to wild-type, indicating rescue of the chondrocyte differentiation delay seen in single Tg(Col2a1-PTHR1*H223R)AHju/0 mice and improvement in endochondral bone formation
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pthlhtm1Hmk mutation
(0 available);
any
Pthlh mutation
(19 available)
Tg(Col2a1-PTHR1*H223R)AHju mutation
(0 available)
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Histological tibiae sections of mice homozygous for Tg(Col2a1-PTHR1*H223R)AHju, mice homozygous for Tg(Col2a1-PTHR1*H223R)AHju and Pthlhtm1Hmk and mice homozygous for Pthlhtm1Hmk
mortality/aging
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• survive up to 2 months compared to death around birth in single Pthlh homozygous null mice
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growth/size/body
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• the odontoblast layer is disorganized
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• number of ameloblasts is reduced
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• tooth eruption is lacking even though tooth buds develop
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• although the endochondral bone formation defect of Pthlh homozygous null mice is rescued, mutant mice are malnourished and grow less than controls
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skeleton
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• the odontoblast layer is disorganized
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• number of ameloblasts is reduced
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• tooth eruption is lacking even though tooth buds develop
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• premature disappearance of the growth plates and their secondary ossification centers
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craniofacial
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• the odontoblast layer is disorganized
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• number of ameloblasts is reduced
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• tooth eruption is lacking even though tooth buds develop
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pthlhtm1Hmk mutation
(0 available);
any
Pthlh mutation
(19 available)
Tg(Col2a1-GAL4)1Amc mutation
(0 available)
Tg(Col2a1-PTHR1*H223R)AHju mutation
(0 available)
Tg(UAS-IHH)1Amc mutation
(0 available)
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skeleton
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• increase in length of the columnar region compared to Pthlh mutant mice that express the constitutively active PTHR1 but do not overexpress IHH
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pthlhtm1Hmk mutation
(0 available);
any
Pthlh mutation
(19 available)
Tg(Col2a1-PTHR1*H223R)AHju mutation
(0 available)
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Alizarin red S stained skeletal images of hemizygous and homozygous Tg(Col2a1-PTHR1*H223R)AHju and Pthlhtm1Hmk/Pthlhtm1Hmk mice
mortality/aging
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• postnatal survival is prolonged for up to 2 months compared to death around birth in single Pthlh homozygous null mice
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skeleton
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N |
• at birth or before birth, mutant skeletons appear normal and do not exhibit premature or abnormal mineralization, indicating rescue by the transgene
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• growth plate of the distal tibia at E17.5 shows relatively normal appearance except for mild shortening of the columnar region and delayed blood vessel invasion
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pth1rtm1Hmk mutation
(0 available);
any
Pth1r mutation
(28 available)
Pth1rtm3Hmk mutation
(0 available);
any
Pth1r mutation
(28 available)
Tg(Col2a1-PTHR1*H223R)AHju mutation
(0 available)
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skeleton
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• expansion of fully differentiated hypertrophic chondrocytes in tibia
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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Skeletal images of wild-type and Tg(Col2a1-PTHR1*H223R)AHju/Tg(Col2a1-PTHR1*H223R)AHju mice
skeleton
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• ossification centers of vertebrae are reduced in size
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• at birth, show reduced or absent mineralization of many elements that develop by endochondral bone formation such as the supraoccipital bone, sternum, ischium and pubic bone
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• sternebrae of newborns have no blood vessel invasion and almost no hypertrophic chondrocytes and the middle part of tibiae are still occupied by cartilage at E17.5
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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Histological sternum sections of wild-type, and mice hemizygous and homozygous for Tg(Col2a1-PTHR1*H223R)AHju
skeleton
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• decrease in the number of hypertrophic chondrocytes
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• ossification centers of vertebrae are reduced in size, however less pronounced than in homozygous transgenic mice
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• metaphyseal chondrodysplasia
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• at birth, show reduced or absent mineralization of many elements that develop by endochondral bone formation such as the supraoccipital bone, sternum, ischium and pubic bone, however, less pronounced than in homozygous transgenic mice
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• impaired endochondral ossification, with extended growth plate length and absence of a clear secondary ossification center
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• sternebrae of newborns have no blood vessel invasion and the middle part of tibiae are still occupied by cartilage at E17.5, however less pronounced than in homozygous transgenic mice
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• delay in chondrocyte differentiation
• decease in chondrocyte apoptosis
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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skeleton
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• expansion of fully differentiated hypertrophic chondrocytes in tibia
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Analysis Tools