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Tg(Upk2-cre)6Xrw
Transgene Detail
Nomenclature
Symbol: Tg(Upk2-cre)6Xrw
Name: transgene insertion 6, Xue-Ru Wu
MGI ID: MGI:3583893
Synonyms: Tg(Upk1b-cre)6Xrw, UPII-Cre
Transgene: Tg(Upk2-cre)6Xrw  Location: unknown  
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Recombinase)
Mutation:    Insertion
 
Mutation detailsA construct was generated having a 3.6 kb fragment of the mouse Upk2 promoter, cre recombinase and a polyA signal. The transgene was purified and microinjected into fertilized FVB/N oocytes. Three founder lines 4,5,6) were obtained, all showing germline transmission and urothelium-specific cre mRNA expression (not detected in any other tissues). Mice established from founder 6 were crossed to reporter mice to verify cre recombinase activity in the urothelium. (J:99613)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Upk2     Summary of all recombinase alleles driven by Upk2.
 

Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:99613 Mo L, et al., Gene deletion in urothelium by specific expression of Cre recombinase. Am J Physiol Renal Physiol. 2005 Sep;289(3):F562-8
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory