Gna13^tm1Cgh
Targeted Allele Detail

Summary

• Symbol: Gna13^tm1Cgh
• Name: guanine nucleotide binding protein, alpha 13; targeted mutation 1, Shaun R Coughlin
• MGI ID: MGI:3583824
• Gene: Gna13 Location: Chr11:109253657-109292195 bp, + strand Genetic Position: Chr11, 71.88 cM
• Alliance: Gna13^tm1Cgh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:99731
• Parent Cell Line: RF8 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The lacZ gene fused in-frame downstream of the first 45 base pairs of exon 1 was inserted in place of exon 1 along with a floxed neomycin resistance cassette. The neo cassette was excised by breeding with mice bearing Tg(ACTB-cre)13Miya. Beta galactosidase activity was detected immunohistochemically. (J:99731)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gna13 Mutation: 12 strains or lines available

References

• Original: J:99731 Ruppel KM, et al., Essential role for Galpha13 in endothelial cells during embryonic development. Proc Natl Acad Sci U S A. 2005 Jun 7;102(23):8281-6
• All: 1 reference(s)