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Cxadrtm1Rwf
Targeted Allele Detail
Nomenclature
Symbol: Cxadrtm1Rwf
Name: coxsackie virus and adenovirus receptor; targeted mutation 1, Robert W Finberg
MGI ID: MGI:3583765
Synonyms: CARdelta2
Gene: Cxadr  Location: Chr16:78301496-78359785 bp, + strand  Genetic Position: Chr16, 45.28 cM, cytoband C
Cxadrtm1Rwf/Cxadrtm1Rwf embryos hemorrhage at E11-11.5

Show the 3 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:99585
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance gene replaced exon 2, which encodes part of the Ig-V-like domain. RT-PCR confirmed splicing of exon 1 directly to exon 3. (J:99585)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cxadr Mutation:  6 strains or lines available
References
Original:  J:99585 Asher DR, et al., Coxsackievirus and adenovirus receptor is essential for cardiomyocyte development. Genesis. 2005 Jun;42(2):77-85
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory