Phenotypes associated with this allele

• Allele Symbol: Cxadr^tm1Rwf
• Allele Name: targeted mutation 1, Robert W Finberg
• Allele ID: MGI:3583765
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cxadr^tm1Rwf/Cxadr^tm1Rwf	involves: 129S6/SvEvTac * C57BL/6	MGI:3584127

Genotype
MGI:3584127

hm1

• Allelic Composition: Cxadr^tm1Rwf/Cxadr^tm1Rwf
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Cxadr^tm1Rwf/Cxadr^tm1Rwf embryos hemorrhage at E11-11.5

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:99585 )

• homozygous embryos die around E11.5

cardiovascular system

thin myocardium ( J:99585 )

hemopericardium ( J:99585 )

• fetal red blood cells are seen in the pericardium along with lesions in the heart

hemothorax ( J:99585 )

• extensive thoracic hemorrhage is seen at E11

muscle

thin myocardium ( J:99585 )

increased cardiomyocyte apoptosis ( J:99585 )

• foci of degenerating cardiomyocytes with signs of apoptosis are seen around E11 in the atrium or ventricular compact wall

• foci are flanked by anuclear swollen cells and the normal elongated epicardial and cardial monolayers are frequently absent around the lesions

• despite the cardiac defects no abnormalities in the placenta are detected

respiratory system

hemothorax ( J:99585 )

• extensive thoracic hemorrhage is seen at E11

homeostasis/metabolism

hemopericardium ( J:99585 )

• fetal red blood cells are seen in the pericardium along with lesions in the heart

cellular

increased cardiomyocyte apoptosis ( J:99585 )

• foci of degenerating cardiomyocytes with signs of apoptosis are seen around E11 in the atrium or ventricular compact wall

• foci are flanked by anuclear swollen cells and the normal elongated epicardial and cardial monolayers are frequently absent around the lesions

• despite the cardiac defects no abnormalities in the placenta are detected