Xist^tm2Sado
Targeted Allele Detail

Summary

• Symbol: Xist^tm2Sado
• Name: inactive X specific transcripts; targeted mutation 2, Takashi Sado
• MGI ID: MGI:3583750
• Synonyms: Xist^1lox
• Gene: Xist Location: ChrX:102503979-102526839 bp, - strand Genetic Position: ChrX, 46.15 cM, cytoband D
• Alliance: Xist^tm2Sado page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:99399
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: The same targeting vector for Xist^tm1Sado was inserted into normal ES cells, thereby replacing part of exon 1 with an IRES-EGFP cassette such that the reporter is under the control of the endogenous promoter. (J:99399)

Expression

In Mice Carrying this Mutation:

10 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Xist Mutation: 8 strains or lines available

References

• Original: J:99399 Sado T, et al., Tsix Silences Xist through Modification of Chromatin Structure. Dev Cell. 2005 Jul;9(1):159-165
• All: 3 reference(s)