Aecp
Allele Detail

Summary

• Symbol: Aecp
• Name: vitamin A enhanced cleft palate
• MGI ID: MGI:3583693
• Gene: Aecp Location: unknown Genetic Position: Chr17, Syntenic
• Alliance: Aecp page

Mutation origin

• Strain of Origin: C57BL/10

Mutation description

• Allele Type: Not Applicable
• Mutation: Undefined
• Mutation details: The b allele at H2-S and H2-D1 is associated with sensitivity to vitamin A induced cleft palate. The d and k alleles at H2-S and H2-D1 are associated with resistance to vitamin A induced cleft palate. (J:103482)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Aecp Mutation: 0 strains or lines available

Notes

Dexamethasone given intraperitoneally on the twelfth day of pregnancy can induce cleft palate in mouse embryos. Two Chr 17 genes control sensitivity to dexamethasone, Dxcp1 and Dxcp2. It has been found that supplementation of the diet of the pregnant dams with excess vitamin A can increase susceptibility to the effect of dexamethasone. The vitamin A effect is mediated by a recessive locus, Aecp, which lies proximal to the Dxcp2 gene (J:4301).

References

• Original: J:4301 Tyan ML, et al., Vitamin A-enhanced cleft palate susceptibility gene maps between C4 and B144 within the H-2 complex. Proc Soc Exp Biol Med. 1993 Apr;202(4):482-6
• All: 2 reference(s)