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Tg(BCR/ABL)623Hkp
Transgene Detail
Summary
Symbol: Tg(BCR/ABL)623Hkp
Name: transgene insertion 623, Nora Heisterkamp
MGI ID: MGI:3582388
Synonyms: BCR-ABL1, P190 BCR-ABL, P190 BCR/ABL
Transgene: Tg(BCR/ABL)623Hkp  Location: unknown  
Alliance: Tg(BCR/ABL)623Hkp page
Transgene
origin
Strain of Origin:  (C57BL/6 x CBA)F2
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(BCR/ABL)623Hkp expresses 2 genes
 
Mutation detailsThe mouse metallothionein-1 promoter drives expression of the human p190 BCR/ABL fusion gene that has the ABL oncogene fused head to tail with the 5' exons of the BCR gene with the break occurring in the first intron. This fusion gene produces the p190 protein with abnormal tyrosin kinase activity. Founder 623 was used to generate the transgenic line. (J:91174)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Tumor Data
List all tumor models in MMHCdb carrying Tg(BCR/ABL)623Hkp
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
References
Original:  J:89786 Voncken JW, et al., Restricted oncogenicity of BCR/ABL p190 in transgenic mice. Cancer Res. 1992 Aug 15;52(16):4534-9
All:  19 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory