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Chrm4tm1Minm
Targeted Allele Detail
Nomenclature
Symbol: Chrm4tm1Minm
Name: cholinergic receptor, muscarinic 4; targeted mutation 1, Minoru Matsui
MGI ID: MGI:3581713
Gene: Chrm4  Location: Chr2:91927249-91928688 bp, + strand  Genetic Position: Chr2, 50.63 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:99248
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA PGK-neo-bpA cassette in the reverse orientation replaced the coding region via homologous recombination. Northern blot analysis confirmed the absence of mRNA in the brain. (J:99248)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Chrm4 Mutation:  21 strains or lines available
References
Original:  J:99248 Karasawa H, et al., Loss of anti-cataleptic effect of scopolamine in mice lacking muscarinic acetylcholine receptor subtype 4. Eur J Pharmacol. 2003 May 2;468(1):15-9
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/05/2017
MGI 6.11
The Jackson Laboratory