All Phenotypes Chrm4<tm1Minm> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Chrm4^tm1Minm
targeted mutation 1, Minoru Matsui
MGI:3581713

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Chrm4^tm1Minm/Chrm4^tm1Minm	involves: 129X1/SvJ * DBA/2J	MGI:3581736

Allelic Composition	Chrm4^tm1Minm/Chrm4^tm1Minm
Genetic Background	involves: 129X1/SvJ * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chrm4^tm1Minm mutation (0 available); any Chrm4 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal behavioral response to xenobiotic ( J:99248 )

• scopolamine, a muscarinic receptor antagonist, could not suppress haloperidol-induced catalepsy as it did in wild-type controls

abnormal locomotor behavior ( J:99248 )

• basal locomotor activity was not different from wildtype, however the enhancement of locomotor activity by a D1 receptor-selective agonist was significantly stronger than in controls

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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