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Cd180tm1Kmiy
Targeted Allele Detail
Nomenclature
Symbol: Cd180tm1Kmiy
Name: CD180 antigen; targeted mutation 1, Kensuke Miyake
MGI ID: MGI:3581654
Synonyms: RP105-
Gene: Cd180  Location: Chr13:102693558-102739629 bp, + strand  Genetic Position: Chr13, 54.92 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:63145
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe sequence in exon 3 encoding most of the extracellular LRR domain, the transmembrane and cytoplasmic domains was replaced with a PGK-neomycin resistance cassette. Flow cytometry failed to detect protein on mutant B cell surfaces. (J:63145)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 5 strains available      Cell Lines: 0 lines available
Carrying any Cd180 Mutation:  25 strains or lines available
References
Original:  J:63145 Ogata H, et al., The toll-like receptor protein RP105 regulates lipopolysaccharide signaling in B cells. J Exp Med. 2000 Jul 3;192(1):23-9
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/10/2017
MGI 6.10
The Jackson Laboratory