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Tlag1C57L/J
QTL Variant Detail
Nomenclature
QTL variant: Tlag1C57L/J
Name: T lymphoma attenuation gene 1; C57L/J
MGI ID: MGI:3581262
QTL: Tlag1  Location: Chr7:87073979-87142720 bp  Genetic Position: Chr7, Syntenic
Variant
origin
Strain of Specimen:  C57L/J
Variant
description
Allele Type:    QTL
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:12885

149 (AKR/J x C57L/J)F2 mice were tested for MNU induced lymphoma tumor incidence (gene Tlag1). An association between Tlag1 and the albino locus was observed in which 50% (20/40) of c/c mice developed tumors whereas only 28% (31/109) of the nonalbino (C/C or C/c) mice did so. In 135 F2 mice there was also a significant association between Hbb and tumor incidence (19/41) over Hbbd/s or Hbbs/ (26/94). There was also a significant association between Hbb and Tyr with Tlag1

J:10061

AKR/J mice are susceptible to MNU inducrd thymic lymphoma. The authors indicate that susceptibility is controlled by several genes. In (AKR/J x C57L/J)F2 mice one gene (Tlag1) was shown associated with the albino locus, since 6/6 albinos had tumors, and only 2/27 nonalbinos had tumors. The association of tumor incidence with the albino locus suggests tight linkage of Tlag1 and Tyrc on mouse Chromosome 7. X2 = 17.8 1 df p <.0001.

References
Original:  J:10061 Angel JM, et al., Genetics of N-methyl-N-nitrosourea induction of thymic lymphomas in AKR/J mice: assignment of a susceptibility gene to mouse chromosome 7. J Natl Cancer Inst. 1989 Nov 1;81(21):1652-5
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/28/2022
MGI 6.20
The Jackson Laboratory