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Ppargtm1Lja
Targeted Allele Detail
Nomenclature
Symbol: Ppargtm1Lja
Name: peroxisome proliferator activated receptor gamma; targeted mutation 1, J Larry Jameson
MGI ID: MGI:3580102
Synonyms: PPARKI
Gene: Pparg  Location: Chr6:115361221-115490401 bp, + strand  Genetic Position: Chr6, 53.41 cM, cytoband E3-F1
Embryonic lethality of Ppargtm1Lja/Ppargtm1Lja mice

Show the 3 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:98786
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted
Mutation:    Nucleotide substitutions
 
Mutation detailsThe leucine residue at codon 466 was changed to alanine due to a CCT to AGC substitution. RT-PCR confirmed equivalent expression of mutant and wild-type alleles. (J:98786)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pparg Mutation:  16 strains or lines available
Notes
Phenotypic Similarity to Human Syndrome: Metabolic Syndrome in mice heterozygous for Ppargtm1Lja (J:98786)

References
Original:  J:98786 Freedman BD, et al., A dominant negative peroxisome proliferator-activated receptor-gamma knock-in mouse exhibits features of the metabolic syndrome. J Biol Chem. 2005 Apr 29;280(17):17118-25
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory