About   Help   FAQ
Ppargtm1Lja
Targeted Allele Detail
Nomenclature
Symbol: Ppargtm1Lja
Name: peroxisome proliferator activated receptor gamma; targeted mutation 1, J Larry Jameson
MGI ID: MGI:3580102
Synonyms: PPARKI
Gene: Pparg  Location: Chr6:115361221-115490401 bp, + strand  Genetic Position: Chr6, 53.41 cM, cytoband E3-F1
Embryonic lethality of Ppargtm1Lja/Ppargtm1Lja mice

Show the 3 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:98786
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted
Mutation:    Nucleotide substitutions
 
Mutation details
Phenotypes
Loading...
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pparg Mutation:  12 strains or lines available
Notes
Phenotypic Similarity to Human Syndrome: Metabolic Syndrome in mice heterozygous for Ppargtm1Lja (J:98786)

References
Original:  J:98786 Freedman BD, et al., A dominant negative peroxisome proliferator-activated receptor-gamma knock-in mouse exhibits features of the metabolic syndrome. J Biol Chem. 2005 Apr 29;280(17):17118-25
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/15/2014
MGI 5.18
The Jackson Laboratory