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Sycp1tm1Aps
Targeted Allele Detail
Nomenclature
Symbol: Sycp1tm1Aps
Name: synaptonemal complex protein 1; targeted mutation 1, Albert Pastink
MGI ID: MGI:3580000
Synonyms: Sycp1-
Gene: Sycp1  Location: Chr3:102818499-102936100 bp, - strand  Genetic Position: Chr3, 45.25 cM, cytoband A3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:98718
Parent Cell Line:  IB10/E14IB10 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin selection cassette replaced exons 2-8, which contains the splice donor sequence of intron 1, the ATG start codon in exon 2 and about 20% of the ORF. The complete lack of protein was confirmed by Western blot of tetstis cell extracts from mutant mice. (J:98718)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sycp1 Mutation:  22 strains or lines available
References
Original:  J:98718 de Vries FA, et al., Mouse Sycp1 functions in synaptonemal complex assembly, meiotic recombination, and XY body formation. Genes Dev. 2005 Jun 1;19(11):1376-89
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory