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Irf8myls
Spontaneous Allele Detail
Nomenclature
Symbol: Irf8myls
Name: interferon regulatory factor 8; myeloproliferative syndrome
MGI ID: MGI:3578920
Synonyms: Icsbp1C294, IRF-8C294, Irf8m, Irf8R294C
Gene: Irf8  Location: Chr8:120736358-120756694 bp, + strand  Genetic Position: Chr8, 70.05 cM
Mutation
origin
Strain of Origin:  BXH2/TyJ
Mutation
description
Allele Type:    Spontaneous
Mutation:    Single point mutation
 
Mutation detailsSequencing revealed a C to T transition at position 915 of cDNA, creating an R294C substitution within the putative IAD domain. (J:97931)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Irf8 Mutation:  8 strains or lines available
References
Original:  J:88564 Turcotte K, et al., Genetic control of myeloproliferation in BXH-2 mice. Blood. 2004 Mar 15;103(6):2343-50
All:  16 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/15/2019
MGI 6.14
The Jackson Laboratory