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Celsr3tm1Agof
Targeted Allele Detail
Nomenclature
Symbol: Celsr3tm1Agof
Name: cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila); targeted mutation 1, Andre M Goffinet
MGI ID: MGI:3578665
Gene: Celsr3  Location: Chr9:108826320-108852969 bp, + strand  Genetic Position: Chr9, 59.63 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:98367
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsA targeting vector was designed to delete exons 19-27. Transcript levels were two- to fourfold lower in mutants than in wild-type animals. RT-PCR confirmed deletion of exons 19-27. A cryptic splice acceptor site in modified intron 27 resulted in an 87-nt 5' extension of exon 28. The resulting protein lacks the GPS, 7TM and C-terminal cytoplasmic sequences. (J:98367)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Celsr3 Mutation:  1 strain or line available
References
Original:  J:98367 Tissir F, et al., Protocadherin Celsr3 is crucial in axonal tract development. Nat Neurosci. 2005 Apr;8(4):451-7
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory