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Arl13bhnn
Chemically induced Allele Detail
Nomenclature
Symbol: Arl13bhnn
Name: ADP-ribosylation factor-like 13B; hennin
MGI ID: MGI:3578151
Gene: Arl13b  Location: Chr16:62793685-62847040 bp, - strand  Genetic Position: Chr16, 36.43 cM, cytoband C1.2
Mutation
origin
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Chemically induced (ENU)
Mutation:    Single point mutation
 
Mutation detailsThis mutation was discovered in a screen of G3 progeny of N-ethyl, N-nitrosourea-treated male mice for morphological defects at embryonic day (e) 9.5. It has been identified as a T-o-G transversion in the splice acceptor sequence of exon 2 which has been shown by RT-PCR to result in exclusion of this exon from mature transcripts and thus of most of a putative GTPase domain, including four consensus nucleotide binding sites, from the protein. Immunoblot analysis reveals the absence of either normally-present protein isoform in mutant embryos. (J:120712)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Arl13b Mutation:  5 strains or lines available
References
Original:  J:98216 Garcia-Garcia MJ, et al., Inaugural Article: Analysis of mouse embryonic patterning and morphogenesis by forward genetics. Proc Natl Acad Sci U S A. 2005 Apr 26;102(17):5913-9
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/04/2020
MGI 6.14
The Jackson Laboratory