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Dicer1tm1Mmk
Targeted Allele Detail
Nomenclature
Symbol: Dicer1tm1Mmk
Name: dicer 1, ribonuclease type III; targeted mutation 1, Matthias Merkenschlager
MGI ID: MGI:3578093
Synonyms: Dicerflox, dicerlox
Gene: Dicer1  Location: Chr12:104687742-104751952 bp, - strand  Genetic Position: Chr12, 54.83 cM, cytoband E-F1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:98192
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsExons 20 and 21, which contain the RNaseII domain, were flanked with loxP sites. A neo with a 5' loxP site was included in the targeting vector and was inserted into intron 19. (J:98192)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dicer1 Mutation:  15 strains or lines available
Notes
Phenotypic Similarity to Human Syndrome: myelodysplastic syndrome (Dicer1tm1Mmk/Dicer1tm1Mmk Tg(Sp7-tTA,tetO-EGFP/cre)1Amc; J:158901)

References
Original:  J:98192 Cobb BS, et al., T cell lineage choice and differentiation in the absence of the RNase III enzyme Dicer. J Exp Med. 2005 May 2;201(9):1367-73
All:  31 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory