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Stat5btm2Jni
Targeted Allele Detail
Nomenclature
Symbol: Stat5btm2Jni
Name: signal transducer and activator of transcription 5B; targeted mutation 2, James N Ihle
MGI ID: MGI:3577898
Synonyms: Stat5ab-, Stat5A/B-, Stat5abdeltaN, Stat5deltaN
Gene: Stat5b  Location: Chr11:100780731-100850724 bp, - strand  Genetic Position: Chr11, 63.63 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:77412
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe first coding exon was replaced by a neomycin resistance cassette via homologous recombination in an ES cell line in which the first two coding exons of Stat5a had already been replaced with a hygromycin resistance cassette. This ES cell line was previously used to produce the Stat5atm1Jni mouse. The Stat5b targeting vector is the same one used to produce the Stat5btm1Jni allele. N-terminally truncated proteins are found at significant levels in the lymphoid lineage by Western Blot analysis (J: 122463). (J:77412, J:122463)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Stat5b Mutation:  5 strains or lines available
Notes
ES cell line = E14 (129P2/OlaHsd) or RW4 (129X1/SvJ).

References
Original:  J:77412 Teglund S, et al., Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses. Cell. 1998 May 29;93(5):841-50
All:  30 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/21/2015
MGI 5.21
The Jackson Laboratory