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Targeted Allele Detail
Symbol: Tgif1tm1Caw
Name: TGFB-induced factor homeobox 1; targeted mutation 1, Christopher A Walsh
MGI ID: MGI:3577048
Synonyms: TgifloxP
Gene: Tgif1  Location: Chr17:71151200-71160527 bp, - strand  Genetic Position: Chr17, 41.87 cM
Germline Transmission:  Earliest citation of germline transmission: J:97642
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S/SvEv
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA targeting vector was used to flank exons 2 and 3 with loxP sites. An FRT-flanked neomycin resistance gene was inserted downstream of the floxed sequence. Crossing with FLPe deleter mice removed the neo. (J:97642)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 14 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tgif1 Mutation:  43 strains or lines available
Original:  J:97642 Shen J, et al., Targeted disruption of tgif, the mouse ortholog of a human holoprosencephaly gene, does not result in holoprosencephaly in mice. Mol Cell Biol. 2005 May;25(9):3639-47
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.19
The Jackson Laboratory