All Phenotypes Tgif1<tm1Caw> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tgif1^tm1Caw/Tgif1^tm1Caw	involves: 129S/SvEv * C57BL/6 * FVB/N	MGI:3716527
cn2	Gli3^tm1Alj/Gli3⁺ Tgif1^tm1Caw/Tgif1^tm1Caw Tgif2^tm1Dwot/Tgif2^tm1Dwot Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺	involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J * CBA	MGI:5791934
cn3	Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺ Tgif1^tm1Caw/Tgif1^tm1Caw Tgif2^tm1Dwot/Tgif2^tm1Dwot	involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA	MGI:4437424
cn4	Nodal^tm1Rob/Nodal⁺ Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺ Tgif1^tm1Caw/Tgif1^tm1Caw Tgif2^tm1Dwot/Tgif2^tm1Dwot	involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA	MGI:4437426

Allelic Composition	Tgif1^tm1Caw/Tgif1^tm1Caw
Genetic Background	involves: 129S/SvEv * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tgif1^tm1Caw mutation (1 available); any Tgif1 mutation (52 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:97642 )

• mice are viable and fertile

Allelic Composition	Gli3^tm1Alj/Gli3⁺ Tgif1^tm1Caw/Tgif1^tm1Caw Tgif2^tm1Dwot/Tgif2^tm1Dwot Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺
Genetic Background	involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3^{Tg(Sox2-cre)1Amc} mutation (5 available); any Edil3 mutation (42 available)
Gli3^tm1Alj mutation (1 available); any Gli3 mutation (80 available)
Tgif1^tm1Caw mutation (1 available); any Tgif1 mutation (52 available)
Tgif2^tm1Dwot mutation (0 available); any Tgif2 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal forebrain development ( J:183402 )

• reduced Gli3 levels partially rescues ventral forebrain morphology observed in double mutants with less disorganization and partially separated cephalic folds

exencephaly ( J:183402 )

• in half of mice at E18.5

decreased embryonic neuroepithelial cell proliferation ( J:183402 )

• at E10.0

embryo

abnormal cephalic neural fold morphology ( J:183402 )

• partially separated cephalic folds

craniofacial

abnormal olfactory epithelium morphology ( J:183402 )

• partially rescued nasal field separation defect

growth/size/body

abnormal olfactory epithelium morphology ( J:183402 )

• partially rescued nasal field separation defect

respiratory system

abnormal olfactory epithelium morphology ( J:183402 )

• partially rescued nasal field separation defect

taste/olfaction

abnormal olfactory epithelium morphology ( J:183402 )

• partially rescued nasal field separation defect

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:157256 )

• present until E10.5

embryonic lethality during organogenesis, incomplete penetrance ( J:183402 )

• most mice do not survive beyond E11.0

nervous system

decreased embryonic neuroepithelium thickness ( J:183402 )

• without any indication of ventral morphology

incomplete rostral neuropore closure ( J:183402 )

• midbrain neural tube fails to close at E9.25

abnormal forebrain morphology ( J:183402 )

• at E10.0

• however, mice exhibit normal forebrain size and morphology at E9.0

abnormal forebrain development ( J:183402 )

• single thickened layer of surface ectoderm in the ventral forebrain and the nasal field has not separated by E10.0

decreased forebrain size ( J:183402 )

decreased embryonic neuroepithelial cell proliferation ( J:183402 )

• at E9.0 and more so at E10.0

embryo

abnormal left-right axis patterning ( J:157256 )

• bilateral expression of normally unilateral genes is seen in the lateral plate mesoderm at E8.5

abnormal cephalic neural fold morphology ( J:183402 )

• fused ventral lips at E8.25

decreased embryonic neuroepithelium thickness ( J:183402 )

• without any indication of ventral morphology

incomplete rostral neuropore closure ( J:183402 )

• midbrain neural tube fails to close at E9.25

abnormal primitive streak elongation ( J:157256 )

• immunofluorescence and immunohistochemical studies suggest AP axis has been specified, and the primitive streak has been induced, but fails to elongate

growth/size/body

abnormal olfactory epithelium morphology ( J:183402 )

• single field

proboscis ( J:183402 )

• in one of the two surviving embryos at E12.5

heterotaxia ( J:183402 )

• left-right asymmetry

respiratory system

abnormal olfactory epithelium morphology ( J:183402 )

• single field

taste/olfaction

abnormal olfactory epithelium morphology ( J:183402 )

• single field

vision/eye

abnormal optic vesicle formation ( J:183402 )

• single small pigmented eye field vesicle

cyclopia ( J:183402 )

• in the two surviving embryos at E12.5

cardiovascular system

abnormal heart looping ( J:157256 )

• in 24% the heart loop has extended dorsoventrally

abnormal direction of heart looping ( J:157256 )

• 35% have a reversal (right to left) of looping direction

failure of heart looping ( J:157256 )

• in about a quarter of embryos the heart extends without looping

craniofacial

abnormal olfactory epithelium morphology ( J:183402 )

• single field

proboscis ( J:183402 )

• in one of the two surviving embryos at E12.5

cellular

increased apoptosis ( J:183402 )

• in the forebrain at E10.0

Allelic Composition	Nodal^tm1Rob/Nodal⁺ Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺ Tgif1^tm1Caw/Tgif1^tm1Caw Tgif2^tm1Dwot/Tgif2^tm1Dwot
Genetic Background	involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3^{Tg(Sox2-cre)1Amc} mutation (5 available); any Edil3 mutation (42 available)
Nodal^tm1Rob mutation (1 available); any Nodal mutation (41 available)
Tgif1^tm1Caw mutation (1 available); any Tgif1 mutation (52 available)
Tgif2^tm1Dwot mutation (0 available); any Tgif2 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal embryonic neuroepithelium morphology ( J:183402 )

• reduced Nodal levels partially rescues ventral neurepithelium morphogenesis observed in double mutants with disorganized neuroepithelium

abnormal forebrain development ( J:183402 )

• reduced Nodal levels partially rescues ventral forebrain morphology observed in double mutants with less disorganization and larger size

• however, forebrain cell proliferation is restored

holoprosencephaly ( J:183402 )

• in mice that survive to E18.5

decreased forebrain size ( J:183402 )

• in two-thirds of mice

embryo

abnormal left-right axis patterning ( J:157256 )

• expression analysis suggests there are some mild defects in left right patterning

rostral body truncation ( J:183402 )

• severe anterior truncation in a small proportion of mice

embryonic growth retardation ( J:183402 )

• in 2 embryos with severe anterior truncation

abnormal embryonic neuroepithelium morphology ( J:183402 )

• reduced Nodal levels partially rescues ventral neurepithelium morphogenesis observed in double mutants with disorganized neuroepithelium

growth/size/body

embryonic growth retardation ( J:183402 )

• in 2 embryos with severe anterior truncation

cardiovascular system

cardiovascular system phenotype ( J:157256 )

N	• unlike in double null mice wild-type for Nodal, heart looping morphogenesis is normal

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