About   Help   FAQ
Drd2tm1Mok
Targeted Allele Detail
Nomenclature
Symbol: Drd2tm1Mok
Name: dopamine receptor D2; targeted mutation 1, Motoya Katsuki
MGI ID: MGI:3576789
Synonyms: D2KO
Gene: Drd2  Location: Chr9:49340662-49407214 bp, + strand  Genetic Position: Chr9, 26.72 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:97838
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe 3' end of exon 2, containing the ATG, was replaced by a neomycin resistance gene to prevent production of either of two possible isoforms. In situ hybridization demonstrated no expression of mRNA in mutant brain samples. (J:97838)
Phenotypes
Loading...
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 19 strains available      Cell Lines: 0 lines available
Carrying any Drd2 Mutation:  45 strains or lines available
References
Original:  J:97838 Yamaguchi H, et al., Dopamine D2 receptor plays a critical role in cell proliferation and proopiomelanocortin expression in the pituitary. Genes Cells. 1996 Feb;1(2):253-68
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/17/2016
MGI 6.05
The Jackson Laboratory