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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Drd2tm1Mok
targeted mutation 1, Motoya Katsuki
MGI:3576789
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Drd2tm1Mok/Drd2tm1Mok involves: 129S/SvEv MGI:3577257
hm2
 		Drd2tm1Mok/Drd2tm1Mok involves: 129S/SvEv * C57BL/6J * DBA/2J MGI:3577255


Genotype
MGI:3577257
hm1
Allelic
Composition		 Drd2tm1Mok/Drd2tm1Mok
Genetic
Background		 involves: 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Drd2tm1Mok mutation (19 available); any Drd2 mutation (70 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal single cell response ( J:97412 )
• the dopamine inhibition concentration-response curve for inhibitory postsynaptic currents of globus pallidus neurons is monophasic unlike the curve for wild-type mice which is biphasic
• dopamine has no effect on the paired-pulse ratio of inhibitory postsynaptic currents of globus pallidus neurons in mutants unlike in wild-type mice




Genotype
MGI:3577255
hm2
Allelic
Composition		 Drd2tm1Mok/Drd2tm1Mok
Genetic
Background		 involves: 129S/SvEv * C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Drd2tm1Mok mutation (19 available); any Drd2 mutation (70 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
enlarged pituitary intermediate lobe ( J:97838 )
• the intermediate lobe is enlarged; however the anterior lobe is normal
abnormal single cell response ( J:97838 )
• in mutant neurons from the substantia nigra compacta 100 um dopamine had no effect on membrane potentials unlike in wild-type neurons where dopamine inhibited spontaneous firing

pigmentation
darkened coat color ( J:97838 )
• agouti coat color is darker with the back darker than other regions of the body

endocrine/exocrine glands
enlarged pituitary intermediate lobe ( J:97838 )
• the intermediate lobe is enlarged; however the anterior lobe is normal

homeostasis/metabolism
abnormal circulating hormone level ( J:97838 )
• alpha-melanocyte stimulating hormone levels are elevated about 15-fold compared to wild-type mice
increased pituitary hormone level ( J:97838 )
• levels of pro-opiomelanocortin are increased in the pituitary; however, levels of prolactin are normal

integument
darkened coat color ( J:97838 )
• agouti coat color is darker with the back darker than other regions of the body




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory