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Txnrd1tm1Marc
Targeted Allele Detail
Nomenclature
Symbol: Txnrd1tm1Marc
Name: thioredoxin reductase 1; targeted mutation 1, Marcus Conrad
MGI ID: MGI:3574358
Synonyms: Txnrd1loxP
Gene: Txnrd1  Location: Chr10:82833951-82897712 bp, + strand  Genetic Position: Chr10, 40.66 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:96818
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsLoxP sites flanking exon 15, which encodes 22 amino acids and the C-terminally located redox center consisting of Gly-Cys-Sec-Gly, and 1.7 kb of the 3' UTR containing the selenocysteine insertion element, essential for cotranslational Sec incorporation at the UGA codon, AU-rich mRNA instability elements and the endogenous transcription stop signal and a neo cassette flanked by frt sites were inserted via homologous recombination. (J:96818)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Txnrd1 Mutation:  41 strains or lines available
References
Original:  J:96818 Jakupoglu C, et al., Cytoplasmic thioredoxin reductase is essential for embryogenesis but dispensable for cardiac development. Mol Cell Biol. 2005 Mar;25(5):1980-8
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory