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H2-Obvic1
Spontaneous Allele Detail
Nomenclature
Symbol: H2-Obvic1
Name: histocompatibility 2, O region beta locus; virus infectivity controller 1
MGI ID: MGI:3573873
Gene: H2-Ob  Location: Chr17:34457879-34464882 bp, + strand  Genetic Position: Chr17, 17.98 cM
Mutation
origin
Strain of Origin:  I/LnJ
Mutation
description
Allele Type:    Spontaneous (Null/knockout)
Mutation:    Nucleotide substitutions
 
Mutation detailsThis I/LnJ loss-of-function variant has eight nucleotide substitutions in the 5-prime and four nucleotide substitutions in the 3-prime non-coding regions and four coding mutations that cause the amino acid substitutions S128N, V148I, L167H, and E239K. (J:254532)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any H2-Ob Mutation:  18 strains or lines available
References
Original:  J:60602 Golovkina TV, A novel mechanism of resistance to mouse mammary tumor virus infection. J Virol. 2000 Mar;74(6):2752-9
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/12/2022
MGI 6.17
The Jackson Laboratory