Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2-Obvic1 mutation
(1 available);
any
H2-Ob mutation
(24 available)
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immune system
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• virus-neutralizing immune response is generated in response to infection with retroviruses
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2-Obvic1 mutation
(1 available);
any
H2-Ob mutation
(24 available)
|
|
|
immune system
|
• virus-neutralizing immune response is generated in response to infection with retroviruses
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2-Obvic1 mutation
(1 available);
any
H2-Ob mutation
(24 available)
|
|
|
immune system
|
• virus-neutralizing immune response is generated in response to infection with retroviruses
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2-Obvic1 mutation
(1 available);
any
H2-Ob mutation
(24 available)
|
|
|
immune system
|
• although MMTV and MuLV infection can occur, MMTV transmission and mammary tumor induction are blocked and MuLV transmission and virally induced disease are blocked, and these responses are mediated by anti-virion antibodies, require gamma interferon, cytotoxic immune responses, but not interleukin 12
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neoplasm
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• mammary glands become infected with MMTV but at 1.5 years zero of 24 infected females develop tumors
(J:81554)
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