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Nbntm2Nus
Targeted Allele Detail
Nomenclature
Symbol: Nbntm2Nus
Name: nibrin; targeted mutation 2, Andre Nussenzweig
MGI ID: MGI:3531643
Synonyms: Nbs1loxP
Gene: Nbn  Location: Chr4:15957925-15992589 bp, + strand  Genetic Position: Chr4, 6.66 cM, cytoband A
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:96102
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA neomycin cassette flanked by loxP sites was introduced into intron 1. A third loxP site was inserted into upstream of exon 1. (J:96102)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nbn Mutation:  40 strains or lines available
References
Original:  J:96102 Reina-San-Martin B, et al., Genomic instability, endoreduplication, and diminished Ig class-switch recombination in B cells lacking Nbs1. Proc Natl Acad Sci U S A. 2005 Feb 1;102(5):1590-5
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory