All Phenotypes Nbn<tm2Nus> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Nbn^tm1Nus/Nbn^tm2Nus Tg(Spo11-cre)D5Mpel/0	involves: BALB/c * C57BL/6	MGI:5297583
cn2	Nbn^tm1Nus/Nbn^tm2Nus Tg(CD19-cre/ERT2)1Cgn/0	Not Specified	MGI:3573788

Allelic Composition	Nbn^tm1Nus/Nbn^tm2Nus Tg(Spo11-cre)D5Mpel/0
Genetic Background	involves: BALB/c * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nbn^tm1Nus mutation (0 available); any Nbn mutation (59 available)
Nbn^tm2Nus mutation (0 available); any Nbn mutation (59 available)
Tg(Spo11-cre)D5Mpel mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:166888 )

N	• in male mutants, no spermatogenic delay or fertility problems are observed

decreased oocyte number ( J:166888 )

• at 5 weeks, about 50% of females show a reduced oocyte number and ovary size

small ovary ( J:166888 )

• at 5 weeks, about 50% of females show a reduced ovary size and oocyte number

endocrine/exocrine glands

small ovary ( J:166888 )

• at 5 weeks, about 50% of females show a reduced ovary size and oocyte number

cellular

decreased oocyte number ( J:166888 )

• at 5 weeks, about 50% of females show a reduced oocyte number and ovary size

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal B cell physiology ( J:96102 )

• recombined B lymphocytes show increased spontaneous DNA damage, chromosomal aberrations including tetraploidy, and Ig class-switch recombination is diminished

decreased B cell proliferation ( J:96102 )

• after 72 hours in culture only 39% of mutant B cells had completed 3 or more cell divisions, cells accumulated in the G₂/M phase of the cell cycle, and relatively increased cell death is seen

decreased IgG level ( J:96102 )

• IgG, IgG1, IgG2b and IgG3 levels are reduced

• IgM levels are normal

decreased IgG1 level ( J:96102 )

decreased IgG2a level ( J:96102 )

decreased IgG2b level ( J:96102 )

decreased IgG3 level ( J:96102 )

hematopoietic system

abnormal B cell physiology ( J:96102 )

• recombined B lymphocytes show increased spontaneous DNA damage, chromosomal aberrations including tetraploidy, and Ig class-switch recombination is diminished

decreased B cell proliferation ( J:96102 )

• after 72 hours in culture only 39% of mutant B cells had completed 3 or more cell divisions, cells accumulated in the G₂/M phase of the cell cycle, and relatively increased cell death is seen

decreased IgG level ( J:96102 )

• IgG, IgG1, IgG2b and IgG3 levels are reduced

• IgM levels are normal

decreased IgG1 level ( J:96102 )

decreased IgG2a level ( J:96102 )

decreased IgG2b level ( J:96102 )

decreased IgG3 level ( J:96102 )

cellular

decreased B cell proliferation ( J:96102 )

• after 72 hours in culture only 39% of mutant B cells had completed 3 or more cell divisions, cells accumulated in the G₂/M phase of the cell cycle, and relatively increased cell death is seen

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Nijmegen breakage syndrome		DOID:7400	OMIM:251260	J:96102

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