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Gene trapped Allele Detail
Symbol: Pknox1Gt(OST71835)Lex
Name: Pbx/knotted 1 homeobox; gene trap OST71835, Lexicon Genetics
MGI ID: MGI:3530910
Synonyms: Pknox1Gt(neo)628Lex, Prep1i
Gene: Pknox1  Location: Chr17:31783708-31826667 bp, + strand  Genetic Position: Chr17, 16.78 cM, cytoband B-C
Alliance: Pknox1Gt(OST71835)Lex page
Mutant Cell Line:  OST71835
Germline Transmission:  Earliest citation of germline transmission: J:103485
Parent Cell Line:  Lex-1 (ES Cell)
Strain of Origin:  129S5/SvEvBrd
Project Collection: Lexicon
Allele Type:    Gene trapped (Hypomorph)
Mutation:    Insertion of gene trap vector
Mutation detailsThe clone used for gene trapping was isolated from a library of embryonic stem cells randomly targeted with the retroviral vector VICTR45 using an enhancer trap strategy. Retroviral insertion occurred at nucleotide 849 of intron 1 located within the 5' untranslated region (2.8 kb from the ATG). RT-PCR analysis revealed that transcript was absent in most homozygous mice. However, in some homozygotes a low level of protein (about 5-10% of wild-type) is detected. (J:103485, J:103769, J:111418)
Sequence Tags: 
Sequence tag details (1 tag)
Genome Context: 
Genome Browser view of this mutation
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 13 assay results
In Structures Affected by this Mutation: 10 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 1 line available
Carrying any Pknox1 Mutation:  79 strains or lines available
See also, data as provided by Lexicon Genetics, Inc.
Original:  J:103485 Lexicon Genetics Inc, NIH initiative supporting placement of Lexicon Genetics, Inc. mice into public repositories. MGI Direct Data Submission. 2005;
All:  21 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory