Suz12^{Gt(Betageo)1Khe}
Gene trapped Allele Detail

Summary

• Symbol: Suz12^{Gt(Betageo)1Khe}
• Name: SUZ12 polycomb repressive complex 2 subunit; gene trap 1, Kristian Helin
• MGI ID: MGI:3530650
• Synonyms: Suz12^-, Suz12^502gt, Suz12^Gt(XG122)Byg
• Gene: Suz12 Location: Chr11:79883932-79924949 bp, + strand Genetic Position: Chr11, 47.36 cM
• Alliance: Suz12^{Gt(Betageo)1Khe} page

Mutation origin

• Mutant Cell Line: XG122
• Germline Transmission: Earliest citation of germline transmission: J:93307
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: pGT1Lxf Vector Type: gene trap
• Mutation details: A gene trap vector inserted into intron 7 which created a truncation containing 276 N-terminal amino acids fused to 1323 amino acids of the Betagalactosidase-neo protein. The translated protein was functionally inactive. (J:93307)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  XG122	CC182865 ; (MGI Seq Detail)	5' RACE	Chr11:79904187-79904419 bp (+)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  21 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Mice Carrying this Mutation:	4 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Suz12 Mutation: 60 strains or lines available

Notes

All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

References

• Original: J:93307 Pasini D, et al., Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity. EMBO J. 2004 Nov 13;23(20):4061-71
• All: 7 reference(s)