Lrp5^{Gt(OST164883)Lex}
Gene trapped Allele Detail

Summary

• Symbol: Lrp5^{Gt(OST164883)Lex}
• Name: low density lipoprotein receptor-related protein 5; gene trap OST164883, Lexicon Genetics
• MGI ID: MGI:3530598
• Synonyms: Lrp5^{Gt(neo)498Lex}
• Gene: Lrp5 Location: Chr19:3634828-3736564 bp, - strand Genetic Position: Chr19, 3.33 cM, cytoband B
• Alliance: Lrp5^{Gt(OST164883)Lex} page

Mutation origin

• Mutant Cell Line: OST164883
• Germline Transmission: Earliest citation of germline transmission: J:133196
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector
• Mutation details: A gene trap vector inserted into the first intron of the gene. RT-PCR analysis of kidney and spleen RNA confirmed that no detectable transcript was expressed from this allele. (J:133196)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  OST164883	CG552927 ; (MGI Seq Detail)	3' RACE	Chr19:3709318-3709525 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  6 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lrp5 Mutation: 81 strains or lines available

References

• Original: J:133196 Iwaniec UT, et al., PTH stimulates bone formation in mice deficient in Lrp5. J Bone Miner Res. 2007 Mar;22(3):394-402
• All: 6 reference(s)