Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp5Gt(OST164883)Lex mutation
(1 available);
any
Lrp5 mutation
(81 available)
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cardiovascular system
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• retinal vasculature is leaky and aberrant compared to in wild-type mice
• the inner and outer plexiform layers lack capillaries unlike in wild-type mice
• retinal vasculature stains positive for a marker of fenestration unlike in wild-type mice
• mice exhibit precapillary arteriolar occlusions in the retinal vasculature unlike in wild-type mice
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• mice exhibit precapillary arteriolar occlusions in the retinal vasculature unlike in wild-type mice
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• retinal vasculature is leaky compared to in wild-type mice
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vision/eye
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• retinal vasculature is leaky and aberrant compared to in wild-type mice
• the inner and outer plexiform layers lack capillaries unlike in wild-type mice
• retinal vasculature stains positive for a marker of fenestration unlike in wild-type mice
• mice exhibit precapillary arteriolar occlusions in the retinal vasculature unlike in wild-type mice
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp5Gt(OST164883)Lex mutation
(1 available);
any
Lrp5 mutation
(81 available)
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skeleton
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• cortical thickness of the femoral diaphysis is decreased 11% compared to in wild-type mice
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• trabecular number and thickness of the lumbar vertebra is reduced compared to in wild-type mice
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• at 6 weeks of age, total and femoral cancellous and cortical bone density are 14% and 16%, respectively, lower than in wild-type mice
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• mice exhibit a 19% decrease in femoral bone density
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• cancellous bone volume is decreased 54% in the distal femur and 38% in the lumbar vertebra compared to in wild-type mice
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• mice exhibit a 30% decrease in femoral cancellous and cortical bone mass
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• at 6 weeks of age, total and femoral cortical bone mass is 23% lower than in wild-type mice
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• at 6 weeks of age, total and femoral cancellous bone mass is 21% lower than in wild-type mice
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• osteoblast surface is reduced 45% compared to in wild-type mice
• bone formation rates are lower due to a decrease in mineralization surface and mineral apposition rate
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• osteoclast surface is reduced 24% in lumbar vertebrae compared to in wild-type mice
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growth/size/body
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• at 20 to 28 weeks of age, mice weigh 9% less than wild-type mice
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Allelic Composition |
Lrp5Gt(OST164883)Lex/Lrp5+ Tspan12tm1Wye/Tspan12+
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Genetic Background |
either: (involves: 129S5/SvEvBrd * C57BL/6) or (involves: 129S5/SvEvBrd * FVB/N) |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp5Gt(OST164883)Lex mutation
(1 available);
any
Lrp5 mutation
(81 available)
Tspan12tm1Wye mutation
(0 available);
any
Tspan12 mutation
(24 available)
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cardiovascular system
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• at P14 and P15, retinal vertical sprouts are reduced compared to in wild-type mice
• retinal vasculature stains positive for a marker of fenestration unlike in wild-type mice
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vision/eye
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• at P14 and P15, retinal vertical sprouts are reduced compared to in wild-type mice
• retinal vasculature stains positive for a marker of fenestration unlike in wild-type mice
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