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Targeted Allele Detail
Symbol: Nod2tm1Mka
Name: nucleotide-binding oligomerization domain containing 2; targeted mutation 1, Michael Karin
MGI ID: MGI:3530578
Synonyms: Nod22939, Nod2mt
Gene: Nod2  Location: Chr8:88647315-88688474 bp, + strand  Genetic Position: Chr8, 43.51 cM, cytoband C3
Germline Transmission:  Earliest citation of germline transmission: J:96128
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Nucleotide substitutions
Mutation detailsA cytosine was inserted at 2939 in exon 11 of the ORF, resulting in a frame-shift leading to a premature stop codon and a truncated protein. The targeting vector contained a neo downstream of the inserted cytosine. RT-PCR and Western blot confirmed successful recombination. (J:96128)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nod2 Mutation:  28 strains or lines available
Original:  J:96128 Maeda S, et al., Nod2 mutation in Crohn's disease potentiates NF-kappaB activity and IL-1beta processing. Science. 2005 Feb 4;307(5710):734-8
All:  3 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.08
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