About   Help   FAQ
Nod2tm1Mka
Targeted Allele Detail
Nomenclature
Symbol: Nod2tm1Mka
Name: nucleotide-binding oligomerization domain containing 2; targeted mutation 1, Michael Karin
MGI ID: MGI:3530578
Synonyms: Nod22939, Nod2mt
Gene: Nod2  Location: Chr8:88647315-88688474 bp, + strand  Genetic Position: Chr8, 43.51 cM, cytoband C3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:96128
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Nucleotide substitutions
 
Mutation detailsA cytosine was inserted at 2939 in exon 11 of the ORF, resulting in a frame-shift leading to a premature stop codon and a truncated protein. The targeting vector contained a neo downstream of the inserted cytosine. RT-PCR and Western blot confirmed successful recombination. (J:96128)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Loading...
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nod2 Mutation:  32 strains or lines available
References
Original:  J:96128 Maeda S, et al., Nod2 mutation in Crohn's disease potentiates NF-kappaB activity and IL-1beta processing. Science. 2005 Feb 4;307(5710):734-8
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/12/2018
MGI 6.12
The Jackson Laboratory