About   Help   FAQ
Mlst8tm1Lex
Targeted Allele Detail
Nomenclature
Symbol: Mlst8tm1Lex
Name: MTOR associated protein, LST8 homolog (S. cerevisiae); targeted mutation 1, Lexicon Genetics
MGI ID: MGI:3528742
Synonyms: mLST8-
Gene: Mlst8  Location: Chr17:24473550-24479078 bp, - strand  Genetic Position: Chr17, 12.39 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:137592
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S5/SvEvBrd
Project Collection: Lexicon
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 2 through 8 were replaced with an IRES-lacz/neo cassette. The absence of protein product was confirmed by western blot. (J:137592)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mlst8 Mutation:  6 strains or lines available
References
Original:  J:137592 Guertin DA, et al., Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1. Dev Cell. 2006 Dec;11(6):859-71
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/10/2018
MGI 6.12
The Jackson Laboratory