Phenotypes associated with this allele

• Allele Symbol: Mlst8^tm1Lex
• Allele Name: targeted mutation 1, Lexicon Genetics
• Allele ID: MGI:3528742
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mlst8^tm1Lex/Mlst8^tm1Lex	involves: 129S5/SvEvBrd	MGI:3802638
cx2	Mlst8^tm1Lex/Mlst8^+ Pten^tm1Rps/Pten^+	involves: 129S1/Sv * 129S5/SvEvBrd * C57BL/6	MGI:4848146

Genotype
MGI:3802638

hm1

• Allelic Composition: Mlst8^tm1Lex/Mlst8^tm1Lex
• Genetic Background: involves: 129S5/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:137592 )

• mice die at around E10.5

embryo

abnormal vitelline vasculature morphology ( J:137592 )

embryonic growth retardation ( J:137592 )

decreased embryo size ( J:137592 )

abnormal placenta morphology ( J:137592 )

• the interface between the trophoblast giant cell layer and the labyrinth is somewhat disorganized

thick placenta labyrinth ( J:137592 )

• thicker than in wild-type mice

nervous system

abnormal brain development ( J:137592 )

• despite no change in apoptosis or cell cycling rates, cephalic regions fail to develop

abnormal telencephalon development ( J:137592 )

• telencephalic vesicles are underdeveloped

cardiovascular system

abnormal vitelline vasculature morphology ( J:137592 )

dilated vasculature ( J:137592 )

• in the head at E10.5

abnormal heart development ( J:137592 )

• the cardiac wall is slightly thinner than in wild-type mice

internal hemorrhage ( J:137592 )

• at E9.5, mice occasionally exhibit internal hemorrhage

growth/size/body

embryonic growth retardation ( J:137592 )

decreased embryo size ( J:137592 )

Genotype
MGI:4848146

cx2

• Allelic Composition: Mlst8^tm1Lex/Mlst8⁺; Pten^tm1Rps/Pten⁺
• Genetic Background: involves: 129S1/Sv * 129S5/SvEvBrd * C57BL/6

mortality/aging

extended life span ( J:144810 )

• double mutants live longer than single heterozygous Pten mice