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Cyldtm1Lex
Targeted Allele Detail
Nomenclature
Symbol: Cyldtm1Lex
Name: CYLD lysine 63 deubiquitinase; targeted mutation 1, Lexicon Genetics
MGI ID: MGI:3528559
Synonyms: Cyld-
Gene: Cyld  Location: Chr8:88697047-88751945 bp, + strand  Genetic Position: Chr8, 43.51 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:114972
Parent Cell Line:  Lex-1 (ES Cell)
Strain of Origin:  129S5/SvEvBrd
Project Collection: Lexicon
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    Exons 2 and 3 were replaced with a lacZ reporter and a neomycin resistance gene. (J:114972)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cyld Mutation:  22 strains or lines available
References
Original:  J:114972 Zhang J, et al., Impaired regulation of NF-kappaB and increased susceptibility to colitis-associated tumorigenesis in CYLD-deficient mice. J Clin Invest. 2006 Nov;116(11):3042-9
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/14/2017
MGI 6.11
The Jackson Laboratory