Phenotypes associated with this allele

• Allele Symbol: Cyld^tm1Lex
• Allele Name: targeted mutation 1, Lexicon Genetics
• Allele ID: MGI:3528559
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cyld^tm1Lex/Cyld^tm1Lex	involves: 129S5/SvEvBrd * C57BL/6	MGI:3691185

Genotype
MGI:3691185

hm1

• Allelic Composition: Cyld^tm1Lex/Cyld^tm1Lex
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:114972 )

• mutants show significantly greater mortality (from severe colitis) than wild-type after second DSS cycle (at 42 days) than wild-type

growth/size/body

weight loss ( J:114972 )

• after first cycle of dextran sodium sulfate (DSS) treatment, mutants lose significantly more weight

behavior/neurological

hunched posture ( J:114972 )

• throughout experiments, mutants appear ill and display a hunched posture

digestive/alimentary system

abnormal intestinal epithelium morphology ( J:114972 )

• more dysplastic changes in colonic epithelium are seen after first DSS treatment than in wild-type

abnormal colon morphology ( J:114972 )

• after DSS treatment, mutants show more severe thickening and shortening of the colon; perforations are frequently observed post-mortem

gastric ulcer ( J:114972 )

• after first DSS treatment, mice show more mucosal ulcers than controls

increased susceptibility to induced colitis ( J:114972 )

• after DSS and azoxymethane (AOM) treatment, mutants display severe colitis at an increased level vs controls

hematopoietic system

thymus hyperplasia ( J:114972 )

• in 10 month-old mutants, marked lymphoid hyperplasia of the thymus is observed

homeostasis/metabolism

abnormal circulating serum albumin level ( J:114972 )

• mice have reduced serum albumin levels

increased incidence of tumors by chemical induction ( J:114972 )

• increase in colonic tumor incidence is observed compared to controls after second DSS cycle; after third cycle, no significant difference in tumor incidence is observed

immune system

immune system phenotype ( J:114972 )

N • thymocyte numbers, and T and B cell numbers are normal compared to wild-type

thymus hyperplasia ( J:114972 )

• in 10 month-old mutants, marked lymphoid hyperplasia of the thymus is observed

abnormal inflammatory response ( J:114972 )

• 10 month-old mice display lymphoid imflammatory infiltrates in the liver, spleen, lungs, and salivary glands

• after first DSS treatment (at 21 days), mice show greater leukocyte infiltration and histologic damage than wild-type

increased susceptibility to induced colitis ( J:114972 )

• after DSS and azoxymethane (AOM) treatment, mutants display severe colitis at an increased level vs controls

neoplasm

increased incidence of tumors by chemical induction ( J:114972 )

• increase in colonic tumor incidence is observed compared to controls after second DSS cycle; after third cycle, no significant difference in tumor incidence is observed

endocrine/exocrine glands

thymus hyperplasia ( J:114972 )

• in 10 month-old mutants, marked lymphoid hyperplasia of the thymus is observed