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Targeted Allele Detail
Symbol: Sema3etm1Ddg
Name: sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E; targeted mutation 1, David D Ginty
MGI ID: MGI:3527995
Synonyms: sema3e-
Gene: Sema3e  Location: Chr5:14025276-14256689 bp, + strand  Genetic Position: Chr5, 5.66 cM
The vascular network is disorganized in Sema3etm1Ddg/Sema3etm1Ddg retinas

Show the 4 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:95697
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA targeting vector was designed to insert an EGFP and a floxed neo at the start codon, deleting the signal peptide in exon 1. In situ hybridization confirmed the absence of mRNA in mutant mice. (J:95697)
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Sema3e Mutation:  34 strains or lines available
Original:  J:95697 Gu C, et al., Semaphorin 3E and plexin-D1 control vascular pattern independently of neuropilins. Science. 2005 Jan 14;307(5707):265-8
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.03
The Jackson Laboratory