Analysis Tools|
Allele Symbol Allele Name Allele ID |
Sema3etm1Ddg targeted mutation 1, David D Ginty MGI:3527995 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at E11.5 the intersomitic vessels are disorganized and extend ectopically throughout the somite
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• at E11.5 ectopic intersomitic vascular growth results in exuberant growth and loss of the normal segmented pattern
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
The vascular network is disorganized in Sema3etm1Ddg/Sema3etm1Ddg retinas
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• at P4, mice exhibit disordered axonal fibers in the retina compared with wild-type mice
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• at P4, mice exhibit vascular defects in the retina with clusters of retinal ECs, attachment of hyaloid vessels to the retinal surface, disorganized vascular, decreased vascular density remodeling, and ectopic vascular invasion into the ganglion cell layer compared to in wild-type mice
• at P4, vascular pathfinding in the retina is restricted compared to in wild-type mice
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• at P4, mice exhibit vascular defects in the retina with clusters of retinal ECs, attachment of hyaloid vessels to the retinal surface, disorganized vascular, decreased vascular density remodeling, and ectopic vascular invasion into the ganglion cell layer compared to in wild-type mice
• at P4, vascular pathfinding in the retina is restricted compared to in wild-type mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 09/30/2025 MGI 6.24 |
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