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Dok1tm1Ppp
Targeted Allele Detail
Nomenclature
Symbol: Dok1tm1Ppp
Name: docking protein 1; targeted mutation 1, Pier Paolo Pandolfi
MGI ID: MGI:3527270
Synonyms: p62dok-
Gene: Dok1  Location: Chr6:83030934-83033471 bp, - strand  Genetic Position: Chr6, 35.94 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:95640
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin selection cassette was used to replace exons 1 through 4 and part of exon 5. Western blot analysis of spleen and thymus did not detect protein gene product. (J:95640)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dok1 Mutation:  7 strains or lines available
References
Original:  J:95640 Di Cristofano A, et al., p62(dok), a negative regulator of Ras and mitogen-activated protein kinase (MAPK) activity, opposes leukemogenesis by p210(bcr-abl). J Exp Med. 2001 Aug 6;194(3):275-84
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/15/2018
MGI 6.12
The Jackson Laboratory