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Il23atm1Dnax
Targeted Allele Detail
Nomenclature
Symbol: Il23atm1Dnax
Name: interleukin 23, alpha subunit p19; targeted mutation 1, DNAX Research Institute of Cellular and Molecular Biology
MGI ID: MGI:3527219
Synonyms: Il-23-, IL23a-, Il23atm1Cua, Il-23p19-, Il23p19tm1Dnax
Gene: Il23a  Location: Chr10:128296140-128298084 bp, - strand  Genetic Position: Chr10, 76.51 cM, cytoband D3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:89968
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neo replaced exons 1-4. Quantitative RT-PCR analysis of mutant lymph node tissue demonstrated the complete lack of transcript. (J:89968)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Il23a Mutation:  12 strains or lines available
References
Original:  J:89968 Cua DJ, et al., Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature. 2003 Feb 13;421(6924):744-8
All:  45 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/14/2017
MGI 6.11
The Jackson Laboratory