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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Il23atm1Dnax
targeted mutation 1, DNAX Research Institute of Cellular and Molecular Biology
MGI:3527219
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Il23atm1Dnax/Il23atm1Dnax B6.Cg-Il23atm1Dnax MGI:3691132
hm2
 		Il23atm1Dnax/Il23atm1Dnax involves: 129 * C57BL/6 MGI:3527418
hm3
 		Il23atm1Dnax/Il23atm1Dnax Not Specified MGI:5476733
cn4
 		Adam17tm1.2Bbl/Adam17tm1.2Bbl
Il23atm1Dnax/Il23atm1Dnax
Sox9tm3(cre)Crm/Sox9+ 		involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * SJL MGI:6241556


Genotype
MGI:3691132
hm1
Allelic
Composition		 Il23atm1Dnax/Il23atm1Dnax
Genetic
Background		 B6.Cg-Il23atm1Dnax
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il23atm1Dnax mutation (0 available); any Il23a mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal granulocyte physiology ( J:111568 )
• fewer than expected granulocytes in the dermis of carcinogen treated skin and the levels of CSF3 are decreased compared to wild-type mice
abnormal CD8-positive, alpha-beta T cell physiology ( J:111568 )
• dramatic increase in the number of cytotoxic CD8+ cells in the dermis and epidermis of carcinogen treated skin
abnormal macrophage physiology ( J:111568 )
• fewer than expected macrophages in the dermis of carcinogen treated skin
abnormal interleukin level ( J:111568 )
• barely detectable levels of IL17 in the skin after carcinogen treatment unlike wild-type mice which express high levels of IL17

neoplasm
decreased incidence of tumors by chemical induction ( J:111568 )
• resistant to induction of papillomas compared to wild-type mice after treatment with DMBA and TPA in a 2 step skin carcinogenesis protocol
• however, there is an increase in the incidence of tumors following intradermal challenge with PDV squamous carcinoma cells

homeostasis/metabolism
abnormal interleukin level ( J:111568 )
• barely detectable levels of IL17 in the skin after carcinogen treatment unlike wild-type mice which express high levels of IL17
decreased incidence of tumors by chemical induction ( J:111568 )
• resistant to induction of papillomas compared to wild-type mice after treatment with DMBA and TPA in a 2 step skin carcinogenesis protocol
• however, there is an increase in the incidence of tumors following intradermal challenge with PDV squamous carcinoma cells

hematopoietic system
abnormal granulocyte physiology ( J:111568 )
• fewer than expected granulocytes in the dermis of carcinogen treated skin and the levels of CSF3 are decreased compared to wild-type mice
abnormal CD8-positive, alpha-beta T cell physiology ( J:111568 )
• dramatic increase in the number of cytotoxic CD8+ cells in the dermis and epidermis of carcinogen treated skin
abnormal macrophage physiology ( J:111568 )
• fewer than expected macrophages in the dermis of carcinogen treated skin




Genotype
MGI:3527418
hm2
Allelic
Composition		 Il23atm1Dnax/Il23atm1Dnax
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il23atm1Dnax mutation (0 available); any Il23a mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal CD4-positive, alpha-beta T cell physiology ( J:95542 )
• CNS-infiltrating CD4+ T cells displayed reduced IL-6 and TNF and undetectable IL-17 production compared to wild-type after EAE induction
decreased interleukin-17 secretion ( J:95542 )
• draining lymph node cells from homozygous mice did not produce IL-17 but had similar IFN-gamma levels as wild-type after EAE induction
decreased susceptibility to experimental autoimmune encephalomyelitis ( J:95542 )
• homozygotes were completely resistant to experimental autoimmune encephalomyelitis (EAE), however comparable numbers of immune cells invaded the central nervous system

hematopoietic system
abnormal CD4-positive, alpha-beta T cell physiology ( J:95542 )
• CNS-infiltrating CD4+ T cells displayed reduced IL-6 and TNF and undetectable IL-17 production compared to wild-type after EAE induction




Genotype
MGI:5476733
hm3
Allelic
Composition		 Il23atm1Dnax/Il23atm1Dnax
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il23atm1Dnax mutation (0 available); any Il23a mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system

homeostasis/metabolism

immune system




Genotype
MGI:6241556
cn4
Allelic
Composition		 Adam17tm1.2Bbl/Adam17tm1.2Bbl
Il23atm1Dnax/Il23atm1Dnax
Sox9tm3(cre)Crm/Sox9+
Genetic
Background		 involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adam17tm1.2Bbl mutation (1 available); any Adam17 mutation (62 available)
Il23atm1Dnax mutation (0 available); any Il23a mutation (25 available)
Sox9tm3(cre)Crm mutation (1 available); any Sox9 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
dermatitis ( J:229771 )
• mice develop eczematous dermatitis

integument
dermatitis ( J:229771 )
• mice develop eczematous dermatitis




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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory