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Adam8tm1Bbl
Targeted Allele Detail
Nomenclature
Symbol: Adam8tm1Bbl
Name: a disintegrin and metallopeptidase domain 8; targeted mutation 1, Carl P Blobel
MGI ID: MGI:3527133
Synonyms: Adam8-
Gene: Adam8  Location: Chr7:139978932-139992562 bp, - strand  Genetic Position: Chr7, 84.96 cM, cytoband F3-F5
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:95366
Parent Cell Line:  E14TG2aIV (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsAn IRES-Beta-galactosidase and neo cassette replaced the catalytic and disintegrin domains. Western blot analysis of lungs confirmed that Adam8 protein was abolished in mutant animals. X-gal staining showed that the endogenous promoter drove lacZ expression in lung tissue. (J:95366)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 12 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Adam8 Mutation:  13 strains or lines available
References
Original:  J:95366 Kelly K, et al., Metalloprotease-disintegrin ADAM8: expression analysis and targeted deletion in mice. Dev Dyn. 2005 Jan;232(1):221-31
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/12/2017
MGI 6.10
The Jackson Laboratory