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Targeted Allele Detail
Symbol: Gata4tm1.1Wtp
Name: GATA binding protein 4; targeted mutation 1.1, William T Pu
MGI ID: MGI:3526854
Synonyms: Gata4flox
Gene: Gata4  Location: Chr14:63198922-63271692 bp, - strand  Genetic Position: Chr14, 33.24 cM
Growth retardation and myocardial thinning in Gata4tm1.1Wtp/Gata4tm1Grg Tg(Nkx2-5-cre)9Eno/0 mice

Show the 5 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:94637
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Conditional ready, Hypomorph)
Mutation:    Insertion
Mutation detailsGata4tm1Wtp mice were crossed with Tg(ACTFLPe)9205Dym to remove the neo, leaving exon 2 floxed. Detailed analysis showed this to be a mild hypomorphic allele. (J:94637)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 4 assay results
In Structures Affected by this Mutation: 10 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gata4 Mutation:  23 strains or lines available
Original:  J:94637 Pu WT, et al., GATA4 is a dosage-sensitive regulator of cardiac morphogenesis. Dev Biol. 2004 Nov 1;275(1):235-44
All:  25 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory