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Epas1tm1Mcs
Targeted Allele Detail
Nomenclature
Symbol: Epas1tm1Mcs
Name: endothelial PAS domain protein 1; targeted mutation 1, M Celeste Simon
MGI ID: MGI:3526731
Synonyms: Epas12lox, Epas1fl, Hif-2alpha 2-lox, HIF-2alpha+f, Hif-2alphafl
Gene: Epas1  Location: Chr17:86753864-86833410 bp, + strand  Genetic Position: Chr17, 56.9 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:119731
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
    Exon 2 was flanked with loxP sites. (J:119731)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Epas1 Mutation:  48 strains or lines available
References
Original:  J:119731 Gruber M, et al., Acute postnatal ablation of Hif-2alpha results in anemia. Proc Natl Acad Sci U S A. 2007 Feb 13;104(7):2301-6
All:  110 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/30/2021
MGI 6.16
The Jackson Laboratory