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Targeted Allele Detail
Symbol: Slc6a1tm1Lst
Name: solute carrier family 6 (neurotransmitter transporter, GABA), member 1; targeted mutation 1, Henry A Lester
MGI ID: MGI:3526678
Synonyms: GAT-1 KO
Gene: Slc6a1  Location: Chr6:114259596-114294491 bp, + strand  Genetic Position: Chr6, 53.05 cM, cytoband E3
Germline Transmission:  Earliest citation of germline transmission: J:80438
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Allele Type:    Targeted (Hypomorph, Reporter)
Mutation:    Insertion
Mutation detailsA floxed neomycin cassette was inserted in intron 14. A GFP gene was inserted in exon 15 at the 3' end of the coding sequence. The resulting mice are hypomorphic with respect to expression. (J:80438, J:95639)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Slc6a1 Mutation:  37 strains or lines available
Original:  J:80438 Chiu CS, et al., Number, density, and surface/cytoplasmic distribution of GABA transporters at presynaptic structures of knock-in mice carrying GABA transporter subtype 1-green fluorescent protein fusions. J Neurosci. 2002 Dec 1;22(23):10251-66
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory