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Fbxw8Gt(RRT057)Byg
Gene trapped Allele Detail
Nomenclature
Symbol: Fbxw8Gt(RRT057)Byg
Name: F-box and WD-40 domain protein 8; gene trap RRT057, BayGenomics
MGI ID: MGI:3526146
Synonyms: Fbxw8Gt(pGTOLxf)1Jdec
Gene: Fbxw8  Location: Chr5:118203046-118293523 bp, - strand  Genetic Position: Chr5, 57.92 cM, cytoband F
Mutation
origin
Mutant Cell Line:  RRT057
Germline Transmission:  Earliest citation of germline transmission: J:130238
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Gene trapped (Hypomorph, Reporter)
Mutation:    Insertion of gene trap vector     Vector: pGT0Lxf     Vector Type: gene trap
 
Mutation detailsA genetrap vector containing a beta-gal reporter and a neomycin selection cassette inserted into intron 3 of the gene locus, 2.6 kb downstream of the exon 3. Western analysis on homozygous embryonic fibroblasts indicated protein expression was at 0.8% of the level in wild-type embryonic fibroblasts. Beta gal expression was detected in numerous tissues of homozygotes including cartilage, skeletal muscle, bronchiolar epithelium, and placenta. (J:130238)
Sequence Tags: 
Sequence tag details (1 tag)
Genome Context: 
Genome Browser view of this mutation
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 26 assay results
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Fbxw8 Mutation:  22 strains or lines available
Notes
All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.
References
Original:  J:130238 Tsutsumi T, et al., Disruption of the Fbxw8 gene results in pre- and postnatal growth retardation in mice. Mol Cell Biol. 2008 Jan;28(2):743-51
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory